Class II Complexes: 90 structures

Kds are equilibrium/steady state values determined by SPR, unless otherwise noted:
k kinetic Kd     b determined by BLI     f determined by FACS

Download table data as CSV file

PDB
ID
TCR
Name
MHC
allele
Release
date
Epitope
TRAV
gene
TRBV
gene
Docking
angle (°)
Incident
angle (°)
Buried
surface
area (Ų)
Shape
complementarity
Kd (µM)

D10
I-Ak
1999-12-15
GNSHRGAIEWEGIESG
TRAV14D-2
TRBV13-2
53.4
6.9
1993.3
0.7
HA1.7
HLA-DR1
2000-11-08
PKYVKQNTLKLAT
TRAV8-4
TRBV28
47.2
2.8
2086.4
0.56
HA1.7
HLA-DR4
2002-03-13
PKYVKQNTLKLAT
TRAV8-4
TRBV28
48.9
1
2111.4
0.56
172.10
I-Au
2005-05-17
SRGGASQYRPSQ
TRAV14-3
TRBV13-2
43.7
0.7
1904.2
0.62
NA
HLA-DR2b
2005-05-03
ENPVVHFFKNIVTPR
TRAV17
TRBV20-1
83.5
18
1993.2
0.51
3A6
HLA-DR2a
2005-10-18
VHFFKNIVTPRTPGG
TRAV9-2
TRBV5-1
40.3
8.7
2224.7
0.61
E8
HLA-DR1
2007-04-03
GELIGILNAAKVPAD
TRAV22
TRBV6-6
44.4
15.6
2188.7
0.69
E8
HLA-DR1
2007-04-03
GELIGTLNAAKVPAD
TRAV22
TRBV6-6
44
15.5
2207.2
0.67
1934.4
I-Au
2007-10-09
HSRGGASQYRPSQ
TRAV6D-7
TRBV13-2
49.1
3.7
1992.9
0.7
NA
HLA-DR2b
2009-04-07
DFARVHFISALHGSG
TRAV17
TRBV20-1
80.3
19.6
2135.3
0.61
cl19
I-Au
2007-10-09
RGGASQYRPSQ
TRAV6D-7
TRBV13-2
48.9
3.1
1976.8
0.64
B3K506
I-Ab
2008-04-29
FEAQKAKANKAVD
TRAV6-7/DV9
TRBV13-3
45.9
11
2224.1
0.56
YAe62
I-Ab
2008-04-29
FEAQKAKANKAVD
TRAV6D-3
TRBV13-2
53.1
6.9
1410.1
0.72
2W20
I-Ab
2008-04-29
FEAQKAKANKAVD
TRAV14-2
TRBV13-2
44.4
2.4
1819.4
0.64
21.30
I-Ag7
2010-05-12
GAMKRHGLDNYRGYSLGN
TRAV4-2
TRBV13-3
48.2
15.1
2687.7
0.6
MS2-3C8
HLA-DR4
2011-03-02
FSWGAEGQRPGFG
TRAV26-2
TRBV20-1
36.4
6
2038.3
0.64
Hy.1B11
HLA-DQ1
2010-12-22
NPVVHFFKNIVTP
TRAV13-1
TRBV7-3
25.3
14.3
1628.5
0.62
2B4
I-Ek
2011-04-27
ADLIAYLKQATKG
TRAV4D-4
TRBV26
36.9
11.8
2567.8
0.72
226
I-Ek
2011-04-27
ADLIAYLKQATKG
TRAV4D-4
TRBV26
39.4
12.1
2453.3
0.67
226
I-Ek
2011-04-27
ADLIAYLEQATKG
TRAV4D-4
TRBV26
40.4
11.9
2452.6
0.64
J809.B5
I-Ab
2011-12-07
FEAQKAKANKAV
TRAV14D-3/DV8
TRBV13-2
41.4
7.2
1529.1
0.75
MS2-3C8
HLA-DR4
2012-03-07
FSWGAEGQRPGFGSGG
TRAV26-2
TRBV20-1
37.5
7.9
2252.4
0.54
G4
HLA-DR1
2012-08-29
GELIGILNAAKVPAD
TRAV22
TRBV5-8
46.6
17.3
2048.9
0.48
SP3.4
HLA-DQ8
2012-10-24
SGEGSFQPSQENP
TRAV26-2
TRBV9
39.9
6.8
1719.1
0.57
Hy.1B11
HLA-DQ1
2013-11-06
RLLMLFAKDVVSR
TRAV13-1
TRBV7-3
26.1
14.6
1792.7
0.65
ANi-2.3
HLA-DR52c
2012-11-14
QHIRCNIPKRISA
TRAV8-3
TRBV19
56
11.6
2124
0.59
Hy.1B11
HLA-DQ1
2013-10-23
QLVHFVRDFAQ
TRAV13-1
TRBV7-3
25.5
14.3
1671.5
0.67
JR5.1
HLA-DQ2.5
2014-04-16
APQPELPYPQPGS
TRAV26-1
TRBV7-2
46.2
13.2
1723.1
0.68
D2
HLA-DQ2.5
2014-04-16
APQPELPYPQPG
TRAV26-1
TRBV7-2
36.1
6.4
2098.8
0.7
S16
HLA-DQ2.5
2014-04-16
APQPELPYPQPGS
TRAV26-1
TRBV7-2
36.2
5.8
2056.7
0.68
S2
HLA-DQ2.5
2014-04-16
QPFPQPELPYP
TRAV4
TRBV20-1
46
21.9
2118.6
0.58
J809.B5
I-Ab
2014-05-28
FEAQKAKANKAV
TRAV14D-3/DV8
TRBV13-2
41.1
6.7
1566.6
0.74
2B4
I-Ek
2014-05-21
ADPLAFFSSAIK
TRAV4D-4
TRBV26
40.1
12.7
2248.5
0.64
5cc7
I-Ek
2014-05-21
ADGLAYFRSSFK
TRAV4D-4
TRBV26
32.2
15.9
2128.2
0.69
5cc7
I-Ek
2014-05-21
ANGVAFFLTPFK
TRAV4D-4
TRBV26
32.3
15.5
2003.3
0.65
J809.B5*
I-Ab
2014-05-28
FEAQKAKANKAV
TRAV14D-3/DV8
TRBV13-2
41.7
7.4
1525.7
0.75
hTCRav22
HLA-DP2
2014-07-16
QAFWIDLFETI
TRAV9-2
TRBV5-1
46.6
24.8
1918.6
0.57
14.C6
I-Ab
2014-05-28
FEAQKAKANKAV
TRAV14D-3/DV8
TRBV13-2
45.3
7.8
1969
0.72
FS18
HLA-DR4
2015-09-23
GSLQPLALEGSLQKRGIV
TRAV29/DV5
TRBV6-2
136.9
43.2
1464.6
0.58
FS17
HLA-DR4
2015-09-23
GSLQPLALEGSLQKRGIV
TRAV29/DV5
TRBV6-2
137.6
44.8
1338
0.45
S13
HLA-DQ8
2015-06-03
APSGEGSFQPSQENPQGS
TRAV26-2
TRBV9
37.9
2.5
1913.8
0.72
L3-12
HLA-DQ8
2015-06-03
APSGEGSFQPSQENPQGS
TRAV26-2
TRBV9
39.6
5.1
1849.8
0.7
T316
HLA-DQ8
2015-06-03
APSGEGSFQPSQENPQGS
TRAV8-3
TRBV6-1
46.1
9
2303.4
0.69
Bel502
HLA-DQ8
2016-09-21
APSGEGSFQPSQENPQ
TRAV20
TRBV9
39.5
8.5
2229.8
0.65
Bel602
HLA-DQ8.5
2016-09-21
QPQQSFPEQEA
TRAV20
TRBV9
42.1
5.5
1856.6
0.78
T15
HLA-DQ8.5
2016-09-21
GPQQSFPEQEA
TRAV20
TRBV9
33.8
11.8
2033.5
0.72
2B4
I-Ek
2018-07-18
ADSLSFFSSSIKRGGGSLVP, YVVVPDGTGGGSGSG
TRAV4D-4
TRBV26
36.6
13.8
2474.1
0.72
F24
HLA-DR11
2018-06-06
RFYKTLRAEQASQ
TRAV24
TRBV2
34.3
5.5
1822.9
0.71
F5
HLA-DR11
2018-06-06
RFYKTLRAEQASQ
TRAV24
TRBV2
33.7
5
1763
0.74
F24
HLA-DR15
2018-06-06
RFYKTLRAEQASQ
TRAV24
TRBV2
35.1
5.3
1806.7
0.69
F24
HLA-DR1
2018-06-06
RFYKTLRAEQASQ
TRAV24
TRBV2
31.4
5.6
1957.8
0.68
I.29
I-Ag7
2019-04-17
LVERLYLVCGEEGA
TRAV10
TRBV1
37.7
16.7
1608.3
0.59
8F10
I-Ag7
2019-04-17
LVERLYLVCGGEG
TRAV5D-4
TRBV13-2
49.4
17.3
1860.5
0.55
T1D3
HLA-DQ8
2019-04-17
VEELYLVAGEEGCGGGGSL
TRAV17
TRBV5-1
35.8
1.7
2138.6
0.69
4699
I-Ab
2019-07-03
RVSYYGPKTSPVQ
TRAV14D-3/DV8
TRBV13-2
42
15.3
1493.1
0.79
5287
I-Ab
2019-07-03
RVSYYGPKTSPVQ
TRAV14D-3/DV8
TRBV13-2
41.6
15.2
1493.2
0.69
4738
I-Ab
2019-07-03
VSYYGPKTSPVQ
TRAV14D-3/DV8
TRBV13-2
46.6
13.8
1487.9
0.75
6256
I-Ab
2019-07-03
RVSYYGPKTSPVQ
TRAV14D-3/DV8
TRBV13-2
43.5
14.4
1500.9
0.78
6236
I-Ab
2019-07-03
RVSYYGPKTSPVQ
TRAV14D-3/DV8
TRBV13-2
46.2
13.5
1482.1
0.76
6235
I-Ab
2019-07-03
RVSYYGPKTSPVQ
TRAV14D-3/DV8
TRBV13-2
44.5
12.8
1493.1
0.77
T1005.2.56
HLA-DQ2.2
2020-01-15
APFSEQEQPVLG
TRAV21
TRBV7-3
30.8
4
2056
0.63
T594
HLA-DQ2.2
2020-01-15
APFSEQEQPVLG
TRAV9-2
TRBV11-2
53.3
14.6
1841.3
0.66
F11
HLA-DR1
2020-07-15
PKYVKQNTLKLAT
TRAV8-4
TRBV24-1
48.6
2.9
2002.1
0.63
LS2.8/3.15
HLA-DQ2.5
2019-12-18
APMPMPELPYP
TRAV8-3
TRBV5-5
34.6
12.2
2192.6
0.62
JR5.1
HLA-DQ2.5
2019-12-18
AVVQSELPYPEGS
TRAV26-1
TRBV7-2
48.2
8.1
1824.9
0.68
M141
HLA-DR4
2020-11-25
GGYPAKAAAT
TRAV6D-6
TRBV4
24
16.7
2008.1
0.63
G08
HLA-DR4
2020-11-25
GGYRAPAKAAAT
TRAV6-5
TRBV4
25.9
16.4
1720.8
0.6
G08
HLA-DR4
2020-11-25
GGYPAKAAAT
TRAV6-5
TRBV4
26
16.1
1640
0.55
M141
HLA-DR4
2020-11-25
GGYRAPAKAAAT
TRAV6D-6
TRBV4
24
16.6
2052.5
0.65
M134
HLA-DR4
2020-11-25
GGYPAKAAAT
TRAV6D-6
TRBV4
24.5
16
1975.8
0.61
M134
HLA-DR4
2020-11-25
GGYRAPAKAAAT
TRAV6D-6
TRBV4
25.5
16.8
1907.3
0.61
A3.10
HLA-DQ8
2021-07-14
GQVELGGGNAVEVCKGS
TRAV38-1
TRBV5-1
32.3
9.9
2385.5
0.7
A1.9
HLA-DQ8
2021-07-14
GQVELGGGNAVEVCK
TRAV20
TRBV5-1
35.5
7
2095
0.72
A2.13
HLA-DQ8
2021-07-14
GQVELGGGNAVEVCKGS
TRAV26-1
TRBV5-1
34.9
5.3
2174.6
0.67
TFH
I-Ad
2022-07-27
EGRVRVNSAYQS
TRAV5D-4
TRBV13-2
42.6
11.9
2303.9
0.65
W316
HLA-DQ2
2022-02-23
QPFPQPEQPFP
TRAV9-2
TRBV7-3
40.5
10.4
1983.6
0.7
XPA5
HLA-DQ2
2022-02-23
QPFPQPELPYGSGGS
TRAV4
TRBV29-1
37.5
14.7
2308.9
0.57
XPA5
HLA-DQ2
2022-02-23
QPFPQPEQPFPGS
TRAV4
TRBV29-1
37.1
14.3
2312.2
0.51
5F
HLA-DP4
2022-12-28
ATGLAWEWWRTVYE
TRAV17
TRBV6-2
36.9
6.5
1912.9
0.49
B5
HLA-DP4
2022-12-28
TGLAWEWWRTVY
TRAV4
TRBV20-1
52.4
13
2298.2
0.68
B1
HLA-DP4
2022-12-28
ATGLAWEWWRTVYE
TRAV19
TRBV7-3
54.5
12.5
1798.4
0.57
4.1
I-Ag7
2022-07-20
LQTLALEVEDDPC
TRAV5D-4
TRBV16
47
4.1
1931.5
0.67
F11
HLA-DRB1
2024-06-19
PKYVKQNTLKLAR
TRAV8-4
TRBV24-1
48.7
2.9
2048.8
 
RA2.7
HLA-DR4
2024-07-31
EIFDSGNPTGEV
TRAV26-1
TRBV2
35.6
3.7
1898.4
0.69
A07
HLA-DR4
2024-07-31
GVYATRSSAVRLR
TRAV6-6
TRBV19
32
8.7
NA
0.63
A03
HLA-DR4
2024-07-31
GVYATSSAVRL
TRAV6-6
TRBV13-3
38.8
9.5
2029.7
0.69
A2.13
HLA-DQ8
2024-08-07
GQVELGGGPGAESCQ
TRAV26-1
TRBV5-1
33
4.3
2198.8
0.63
A2.13
HLA-DQ8
2024-08-07
GQVELGGGSSPETCI
TRAV26-1
TRBV5-1
33.7
3.7
2126
0.74
ET650-4
HLA-DQ8
2024-08-07
GQVELGGGNAVEVCKG
TRAV26-1
TRBV5-1
NA
NA
NA
0.73
ET650-4
HLA-DQ8
2024-08-07
GQVELGGGTPIESC
TRAV26-1
TRBV5-1
40.3
5.2
2360.8
0.76